FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation

FBXW2 is an F-box protein that target substrates for degradation through SCF E3 ligase. Here, the authors show that FBXW2 suppresses lung cancer migration and invasion by promoting degradation of β-catenin and this is dependent on EGF-AKT1.

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Autores principales:	Fei Yang, Jie Xu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bdd0e3ba0f94b198831ab812a2cd975
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spelling	oai:doaj.org-article:1bdd0e3ba0f94b198831ab812a2cd9752021-12-02T15:35:56ZFBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation10.1038/s41467-019-09289-52041-1723https://doaj.org/article/1bdd0e3ba0f94b198831ab812a2cd9752019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09289-5https://doaj.org/toc/2041-1723FBXW2 is an F-box protein that target substrates for degradation through SCF E3 ligase. Here, the authors show that FBXW2 suppresses lung cancer migration and invasion by promoting degradation of β-catenin and this is dependent on EGF-AKT1.Fei YangJie XuHua LiMingjia TanXiufang XiongYi SunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Yang Jie Xu Hua Li Mingjia Tan Xiufang Xiong Yi Sun FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
description	FBXW2 is an F-box protein that target substrates for degradation through SCF E3 ligase. Here, the authors show that FBXW2 suppresses lung cancer migration and invasion by promoting degradation of β-catenin and this is dependent on EGF-AKT1.
format	article
author	Fei Yang Jie Xu Hua Li Mingjia Tan Xiufang Xiong Yi Sun
author_facet	Fei Yang Jie Xu Hua Li Mingjia Tan Xiufang Xiong Yi Sun
author_sort	Fei Yang
title	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
title_short	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
title_full	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
title_fullStr	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
title_full_unstemmed	FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
title_sort	fbxw2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1bdd0e3ba0f94b198831ab812a2cd975
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FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation

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