Discovery of clinically relevant fusions in pediatric cancer

Discovery of clinically relevant fusions in pediatric cancer

Abstract Background Pediatric cancers typically have a distinct genomic landscape when compared to adult cancers and frequently carry somatic gene fusion events that alter gene expression and drive tumorigenesis. Sensitive and specific detection of gene fusions through the analysis of next-generatio...

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Main Authors: Stephanie LaHaye, James R. Fitch, Kyle J. Voytovich, Adam C. Herman, Benjamin J. Kelly, Grant E. Lammi, Jeremy A. Arbesfeld, Saranga Wijeratne, Samuel J. Franklin, Kathleen M. Schieffer, Natalie Bir, Sean D. McGrath, Anthony R. Miller, Amy Wetzel, Katherine E. Miller, Tracy A. Bedrosian, Kristen Leraas, Elizabeth A. Varga, Kristy Lee, Ajay Gupta, Bhuvana Setty, Daniel R. Boué, Jeffrey R. Leonard, Jonathan L. Finlay, Mohamed S. Abdelbaki, Diana S. Osorio, Selene C. Koo, Daniel C. Koboldt, Alex H. Wagner, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Vincent Magrini, Catherine E. Cottrell, Elaine R. Mardis, Richard K. Wilson, Peter White
Format: article
Language:EN
Published: BMC 2021
Subjects:
Transcriptomics
Genomics
Pediatric neoplasms
Gene fusions
Cancer
RNA-Seq
Biotechnology
TP248.13-248.65
Genetics
QH426-470
Online Access:https://doaj.org/article/1bf38c799d7f4ba18515aabb9dbe24f1
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https://doaj.org/article/1bf38c799d7f4ba18515aabb9dbe24f1

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