SPA70 is a potent antagonist of human pregnane X receptor

The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the structurally related agonist SJB7.

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Autores principales:	Wenwei Lin, Yue-Ming Wang, Sergio C. Chai, Lili Lv, Jie Zheng, Jing Wu, Qijun Zhang, Yong-Dong Wang, Patrick R. Griffin, Taosheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c0bb2294d6a40f4b4d18bb1cc20c813
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spelling	oai:doaj.org-article:1c0bb2294d6a40f4b4d18bb1cc20c8132021-12-02T14:41:09ZSPA70 is a potent antagonist of human pregnane X receptor10.1038/s41467-017-00780-52041-1723https://doaj.org/article/1c0bb2294d6a40f4b4d18bb1cc20c8132017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00780-5https://doaj.org/toc/2041-1723The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the structurally related agonist SJB7.Wenwei LinYue-Ming WangSergio C. ChaiLili LvJie ZhengJing WuQijun ZhangYong-Dong WangPatrick R. GriffinTaosheng ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenwei Lin Yue-Ming Wang Sergio C. Chai Lili Lv Jie Zheng Jing Wu Qijun Zhang Yong-Dong Wang Patrick R. Griffin Taosheng Chen SPA70 is a potent antagonist of human pregnane X receptor
description	The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the structurally related agonist SJB7.
format	article
author	Wenwei Lin Yue-Ming Wang Sergio C. Chai Lili Lv Jie Zheng Jing Wu Qijun Zhang Yong-Dong Wang Patrick R. Griffin Taosheng Chen
author_facet	Wenwei Lin Yue-Ming Wang Sergio C. Chai Lili Lv Jie Zheng Jing Wu Qijun Zhang Yong-Dong Wang Patrick R. Griffin Taosheng Chen
author_sort	Wenwei Lin
title	SPA70 is a potent antagonist of human pregnane X receptor
title_short	SPA70 is a potent antagonist of human pregnane X receptor
title_full	SPA70 is a potent antagonist of human pregnane X receptor
title_fullStr	SPA70 is a potent antagonist of human pregnane X receptor
title_full_unstemmed	SPA70 is a potent antagonist of human pregnane X receptor
title_sort	spa70 is a potent antagonist of human pregnane x receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1c0bb2294d6a40f4b4d18bb1cc20c813
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SPA70 is a potent antagonist of human pregnane X receptor

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