Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted...

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Autores principales:	Nicolas Rochereau, Eva Michaud, Louis Waeckel, Martin Killian, Rémi Gayet, Roman Goguyer-Deschaumes, Xavier Roblin, Gilles Biolley, Blaise Corthésy, Stéphane Paul
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f
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spelling	oai:doaj.org-article:1c0d9dd7c688430d9d5f4ebbadbdf92f2021-11-18T04:47:54ZEssential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis2211-124710.1016/j.celrep.2021.110006https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014844https://doaj.org/toc/2211-1247Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.Nicolas RochereauEva MichaudLouis WaeckelMartin KillianRémi GayetRoman Goguyer-DeschaumesXavier RoblinGilles BiolleyBlaise CorthésyStéphane PaulElsevierarticleIgMTOSO/FAIM3reverse transcytosismicrofold cellBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 7, Pp 110006- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) QH301-705.5
spellingShingle	IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) QH301-705.5 Nicolas Rochereau Eva Michaud Louis Waeckel Martin Killian Rémi Gayet Roman Goguyer-Deschaumes Xavier Roblin Gilles Biolley Blaise Corthésy Stéphane Paul Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
description	Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
format	article
author	Nicolas Rochereau Eva Michaud Louis Waeckel Martin Killian Rémi Gayet Roman Goguyer-Deschaumes Xavier Roblin Gilles Biolley Blaise Corthésy Stéphane Paul
author_facet	Nicolas Rochereau Eva Michaud Louis Waeckel Martin Killian Rémi Gayet Roman Goguyer-Deschaumes Xavier Roblin Gilles Biolley Blaise Corthésy Stéphane Paul
author_sort	Nicolas Rochereau
title	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
title_short	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
title_full	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
title_fullStr	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
title_full_unstemmed	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
title_sort	essential role of toso/faim3 in intestinal igm reverse transcytosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f
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Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

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