Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

Higgins et al. present a cycloalkane-modified amphiphilic polymer that can provide direct extraction of membrane proteins for Cryo-EM analysis. They show its utility by extracting and solving the structure of AcrB to a high resolution of 3.2 Å by single particle cryo-EM.

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Autores principales:	Anna J. Higgins, Alex J. Flynn, Anaïs Marconnet, Laura J. Musgrove, Vincent L. G. Postis, Jonathan D. Lippiat, Chun-wa Chung, Tom Ceska, Manuela Zoonens, Frank Sobott, Stephen P. Muench
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1c131cd75303428686e3487d6389ace3
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spelling	oai:doaj.org-article:1c131cd75303428686e3487d6389ace32021-11-28T12:10:15ZCycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis10.1038/s42003-021-02834-32399-3642https://doaj.org/article/1c131cd75303428686e3487d6389ace32021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02834-3https://doaj.org/toc/2399-3642Higgins et al. present a cycloalkane-modified amphiphilic polymer that can provide direct extraction of membrane proteins for Cryo-EM analysis. They show its utility by extracting and solving the structure of AcrB to a high resolution of 3.2 Å by single particle cryo-EM.Anna J. HigginsAlex J. FlynnAnaïs MarconnetLaura J. MusgroveVincent L. G. PostisJonathan D. LippiatChun-wa ChungTom CeskaManuela ZoonensFrank SobottStephen P. MuenchNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anna J. Higgins Alex J. Flynn Anaïs Marconnet Laura J. Musgrove Vincent L. G. Postis Jonathan D. Lippiat Chun-wa Chung Tom Ceska Manuela Zoonens Frank Sobott Stephen P. Muench Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
description	Higgins et al. present a cycloalkane-modified amphiphilic polymer that can provide direct extraction of membrane proteins for Cryo-EM analysis. They show its utility by extracting and solving the structure of AcrB to a high resolution of 3.2 Å by single particle cryo-EM.
format	article
author	Anna J. Higgins Alex J. Flynn Anaïs Marconnet Laura J. Musgrove Vincent L. G. Postis Jonathan D. Lippiat Chun-wa Chung Tom Ceska Manuela Zoonens Frank Sobott Stephen P. Muench
author_facet	Anna J. Higgins Alex J. Flynn Anaïs Marconnet Laura J. Musgrove Vincent L. G. Postis Jonathan D. Lippiat Chun-wa Chung Tom Ceska Manuela Zoonens Frank Sobott Stephen P. Muench
author_sort	Anna J. Higgins
title	Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
title_short	Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
title_full	Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
title_fullStr	Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
title_full_unstemmed	Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
title_sort	cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for cryoem analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c131cd75303428686e3487d6389ace3
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Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

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