Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes

Summary: Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do not mitigate clinical endpoint risk. Populati...

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Autores principales: Sushmita L. Allam, Timothy H. Rumbell, Tuan Hoang-Trong, Jaimit Parikh, James R. Kozloski
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/1c7b6625b6fe493881da67d82223dbf5
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