Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes
Summary: Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do not mitigate clinical endpoint risk. Populati...
Guardado en:
Autores principales: | Sushmita L. Allam, Timothy H. Rumbell, Tuan Hoang-Trong, Jaimit Parikh, James R. Kozloski |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/1c7b6625b6fe493881da67d82223dbf5 |
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