Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens

Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen presentation and CD8+ T cell activation and showed g...

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Autores principales: Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, David Bouyssié, Emmanuelle Mouton-Barbosa, Julien Marcoux, Camille Garcia, Michael Ghosh, Mouad Alami, Sébastien Apcher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1c8392da73b6409daf3965425089b16d
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