The design of a Bayesian adaptive clinical trial of tranexamic acid in severely injured children

The design of a Bayesian adaptive clinical trial of tranexamic acid in severely injured children

Abstract Background Trauma is the leading cause of death and disability in children in the USA. Tranexamic acid (TXA) reduces the blood transfusion requirements in adults and children during surgery. Several studies have evaluated TXA in adults with hemorrhagic trauma, but no randomized controlled t...

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Bibliographic Details
Main Authors: John M. VanBuren, T. Charles Casper, Daniel K. Nishijima, Nathan Kuppermann, Roger J. Lewis, J. Michael Dean, Anna McGlothlin, For the TIC-TOC Collaborators of the Pediatric Emergency Care Applied Research Network (PECARN)
Format: article
Language:EN
Published: BMC 2021
Subjects:
Bayesian statistics
Tranexamic acid
Pediatrics
Adaptive clinical trial design
Response-adaptive randomization
Dose-response
Medicine (General)
R5-920
Online Access:https://doaj.org/article/1cc18e06b8e348a38442702dd6d5bb1c
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https://doaj.org/article/1cc18e06b8e348a38442702dd6d5bb1c

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