Structure and function of the Orc1 BAH-nucleosome complex

The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetyl...

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Bibliographic Details
Main Authors: Pablo De Ioannes, Victor A. Leon, Zheng Kuang, Miao Wang, Jef D. Boeke, Andreas Hochwagen, Karim-Jean Armache
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/1cec6b48299e488d97d26035f5611a1a
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