Structure and function of the Orc1 BAH-nucleosome complex

The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetyl...

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Autores principales:	Pablo De Ioannes, Victor A. Leon, Zheng Kuang, Miao Wang, Jef D. Boeke, Andreas Hochwagen, Karim-Jean Armache
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cec6b48299e488d97d26035f5611a1a
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spelling	oai:doaj.org-article:1cec6b48299e488d97d26035f5611a1a2021-12-02T16:58:14ZStructure and function of the Orc1 BAH-nucleosome complex10.1038/s41467-019-10609-y2041-1723https://doaj.org/article/1cec6b48299e488d97d26035f5611a1a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10609-yhttps://doaj.org/toc/2041-1723The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetylation; a modification that regulates accessibility to chromatin.Pablo De IoannesVictor A. LeonZheng KuangMiao WangJef D. BoekeAndreas HochwagenKarim-Jean ArmacheNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pablo De Ioannes Victor A. Leon Zheng Kuang Miao Wang Jef D. Boeke Andreas Hochwagen Karim-Jean Armache Structure and function of the Orc1 BAH-nucleosome complex
description	The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetylation; a modification that regulates accessibility to chromatin.
format	article
author	Pablo De Ioannes Victor A. Leon Zheng Kuang Miao Wang Jef D. Boeke Andreas Hochwagen Karim-Jean Armache
author_facet	Pablo De Ioannes Victor A. Leon Zheng Kuang Miao Wang Jef D. Boeke Andreas Hochwagen Karim-Jean Armache
author_sort	Pablo De Ioannes
title	Structure and function of the Orc1 BAH-nucleosome complex
title_short	Structure and function of the Orc1 BAH-nucleosome complex
title_full	Structure and function of the Orc1 BAH-nucleosome complex
title_fullStr	Structure and function of the Orc1 BAH-nucleosome complex
title_full_unstemmed	Structure and function of the Orc1 BAH-nucleosome complex
title_sort	structure and function of the orc1 bah-nucleosome complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1cec6b48299e488d97d26035f5611a1a
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Structure and function of the Orc1 BAH-nucleosome complex

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