Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is required for stable gene re-expression.

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Auteurs principaux: David Cano-Rodriguez, Rutger A F. Gjaltema, Laura J Jilderda, Pytrick Jellema, Jelleke Dokter-Fokkens, Marcel H J. Ruiters, Marianne G Rots
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/1cf7c874be9f48f397c7ca7806d63fe8
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