Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is required for stable gene re-expression.

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Autores principales:	David Cano-Rodriguez, Rutger A F. Gjaltema, Laura J Jilderda, Pytrick Jellema, Jelleke Dokter-Fokkens, Marcel H J. Ruiters, Marianne G Rots
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1cf7c874be9f48f397c7ca7806d63fe8
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spelling	oai:doaj.org-article:1cf7c874be9f48f397c7ca7806d63fe82021-12-02T14:39:13ZWriting of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner10.1038/ncomms122842041-1723https://doaj.org/article/1cf7c874be9f48f397c7ca7806d63fe82016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12284https://doaj.org/toc/2041-1723Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is required for stable gene re-expression.David Cano-RodriguezRutger A F. GjaltemaLaura J JilderdaPytrick JellemaJelleke Dokter-FokkensMarcel H J. RuitersMarianne G RotsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Cano-Rodriguez Rutger A F. Gjaltema Laura J Jilderda Pytrick Jellema Jelleke Dokter-Fokkens Marcel H J. Ruiters Marianne G Rots Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
description	Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is required for stable gene re-expression.
format	article
author	David Cano-Rodriguez Rutger A F. Gjaltema Laura J Jilderda Pytrick Jellema Jelleke Dokter-Fokkens Marcel H J. Ruiters Marianne G Rots
author_facet	David Cano-Rodriguez Rutger A F. Gjaltema Laura J Jilderda Pytrick Jellema Jelleke Dokter-Fokkens Marcel H J. Ruiters Marianne G Rots
author_sort	David Cano-Rodriguez
title	Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
title_short	Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
title_full	Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
title_fullStr	Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
title_full_unstemmed	Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
title_sort	writing of h3k4me3 overcomes epigenetic silencing in a sustained but context-dependent manner
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1cf7c874be9f48f397c7ca7806d63fe8
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Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

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