Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in...

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Autores principales:	Sunhee Hwang, Karen Mruk, Simin Rahighi, Andrew G. Raub, Che-Hong Chen, Lisa E. Dorn, Naoki Horikoshi, Soichi Wakatsuki, James K. Chen, Daria Mochly-Rosen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a
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spelling	oai:doaj.org-article:1d179241d985451cb9ca3ac72357b58a2021-12-02T15:34:49ZCorrecting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator10.1038/s41467-018-06447-z2041-1723https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06447-zhttps://doaj.org/toc/2041-1723Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in zebrafish and hemolysis in isolated human erythrocytes.Sunhee HwangKaren MrukSimin RahighiAndrew G. RaubChe-Hong ChenLisa E. DornNaoki HorikoshiSoichi WakatsukiJames K. ChenDaria Mochly-RosenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sunhee Hwang Karen Mruk Simin Rahighi Andrew G. Raub Che-Hong Chen Lisa E. Dorn Naoki Horikoshi Soichi Wakatsuki James K. Chen Daria Mochly-Rosen Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
description	Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in zebrafish and hemolysis in isolated human erythrocytes.
format	article
author	Sunhee Hwang Karen Mruk Simin Rahighi Andrew G. Raub Che-Hong Chen Lisa E. Dorn Naoki Horikoshi Soichi Wakatsuki James K. Chen Daria Mochly-Rosen
author_facet	Sunhee Hwang Karen Mruk Simin Rahighi Andrew G. Raub Che-Hong Chen Lisa E. Dorn Naoki Horikoshi Soichi Wakatsuki James K. Chen Daria Mochly-Rosen
author_sort	Sunhee Hwang
title	Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
title_short	Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
title_full	Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
title_fullStr	Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
title_full_unstemmed	Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
title_sort	correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a
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Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

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