Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.

Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.

HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis, viral persistence, and HIV-associated comorbidities. Here, we examined how soon after infection HIV-associated epigenetic changes may occur in blood and whether early initiation of antiretroviral therapy (ART) i...

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Autores principales: Michael J Corley, Carlo Sacdalan, Alina P S Pang, Nitiya Chomchey, Nisakorn Ratnaratorn, Victor Valcour, Eugene Kroon, Kyu S Cho, Andrew C Belden, Donn Colby, Merlin Robb, Denise Hsu, Serena Spudich, Robert Paul, Sandhya Vasan, Lishomwa C Ndhlovu, SEARCH010/RV254 and SEARCH013/RV304 study groups
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1d2a126202fa4f6dbc8e432b92230853
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https://doaj.org/article/1d2a126202fa4f6dbc8e432b92230853

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