Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.
HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis, viral persistence, and HIV-associated comorbidities. Here, we examined how soon after infection HIV-associated epigenetic changes may occur in blood and whether early initiation of antiretroviral therapy (ART) i...
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Autores principales: | Michael J Corley, Carlo Sacdalan, Alina P S Pang, Nitiya Chomchey, Nisakorn Ratnaratorn, Victor Valcour, Eugene Kroon, Kyu S Cho, Andrew C Belden, Donn Colby, Merlin Robb, Denise Hsu, Serena Spudich, Robert Paul, Sandhya Vasan, Lishomwa C Ndhlovu, SEARCH010/RV254 and SEARCH013/RV304 study groups |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/1d2a126202fa4f6dbc8e432b92230853 |
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