Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation

Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctional proteins. Chronic stress resulting from translation errors may be particularly relevant in tissues that must synthesize and secrete large amounts of secretory proteins. Here, we studied the proteost...

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Bibliographic Details
Main Authors: James Moore, Ivan Osinnii, Amandine Grimm, Björn Oettinghaus, Anne Eckert, Stephan Frank, Erik C. Böttger
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/1d4f3cec56d341cc86354d93001d0c3c
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