Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Abstract Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selective...

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Autores principales: Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, Ricarda Diem
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
TNF Receptor (TNFR1)
Immune Cell Composition
Central Nervous System Immune Cells
Experimental Autoimmune Encephalomyelitis
Anti-drug Antibodies (ADAs)
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1d5fda7e325a49d7ac87de90f8d6525b
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https://doaj.org/article/1d5fda7e325a49d7ac87de90f8d6525b

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