Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Abstract Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selective...

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Bibliographic Details
Main Authors:	Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, Ricarda Diem
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	TNF Receptor (TNFR1) Immune Cell Composition Central Nervous System Immune Cells Experimental Autoimmune Encephalomyelitis Anti-drug Antibodies (ADAs) Medicine R Science Q
Online Access:	https://doaj.org/article/1d5fda7e325a49d7ac87de90f8d6525b
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Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

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