Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder

Epigenetic mechanisms have emerged as contributors to the molecular impairments caused by exposure to environmental factors such as abused substances. Here the authors perform epigenetic profiling of the striatum and identify the tyrosine kinase FYN is an important driver of neurodegenerative-like p...

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Autores principales:	Gabor Egervari, Diana Akpoyibo, Tanni Rahman, John F. Fullard, James E. Callens, Joseph A. Landry, Annie Ly, Xianxiao Zhou, Noël Warren, Mads E. Hauberg, Gabriel Hoffman, Randy Ellis, Jacqueline-Marie N. Ferland, Michael L. Miller, Eva Keller, Bin Zhang, Panos Roussos, Yasmin L. Hurd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d88bd91ce5342d1ae6c9fd044545db3
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spelling	oai:doaj.org-article:1d88bd91ce5342d1ae6c9fd044545db32021-12-02T15:15:59ZChromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder10.1038/s41467-020-18114-32041-1723https://doaj.org/article/1d88bd91ce5342d1ae6c9fd044545db32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18114-3https://doaj.org/toc/2041-1723Epigenetic mechanisms have emerged as contributors to the molecular impairments caused by exposure to environmental factors such as abused substances. Here the authors perform epigenetic profiling of the striatum and identify the tyrosine kinase FYN is an important driver of neurodegenerative-like pathology and drug-taking behaviour.Gabor EgervariDiana AkpoyiboTanni RahmanJohn F. FullardJames E. CallensJoseph A. LandryAnnie LyXianxiao ZhouNoël WarrenMads E. HaubergGabriel HoffmanRandy EllisJacqueline-Marie N. FerlandMichael L. MillerEva KellerBin ZhangPanos RoussosYasmin L. HurdNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabor Egervari Diana Akpoyibo Tanni Rahman John F. Fullard James E. Callens Joseph A. Landry Annie Ly Xianxiao Zhou Noël Warren Mads E. Hauberg Gabriel Hoffman Randy Ellis Jacqueline-Marie N. Ferland Michael L. Miller Eva Keller Bin Zhang Panos Roussos Yasmin L. Hurd Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
description	Epigenetic mechanisms have emerged as contributors to the molecular impairments caused by exposure to environmental factors such as abused substances. Here the authors perform epigenetic profiling of the striatum and identify the tyrosine kinase FYN is an important driver of neurodegenerative-like pathology and drug-taking behaviour.
format	article
author	Gabor Egervari Diana Akpoyibo Tanni Rahman John F. Fullard James E. Callens Joseph A. Landry Annie Ly Xianxiao Zhou Noël Warren Mads E. Hauberg Gabriel Hoffman Randy Ellis Jacqueline-Marie N. Ferland Michael L. Miller Eva Keller Bin Zhang Panos Roussos Yasmin L. Hurd
author_facet	Gabor Egervari Diana Akpoyibo Tanni Rahman John F. Fullard James E. Callens Joseph A. Landry Annie Ly Xianxiao Zhou Noël Warren Mads E. Hauberg Gabriel Hoffman Randy Ellis Jacqueline-Marie N. Ferland Michael L. Miller Eva Keller Bin Zhang Panos Roussos Yasmin L. Hurd
author_sort	Gabor Egervari
title	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
title_short	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
title_full	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
title_fullStr	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
title_full_unstemmed	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
title_sort	chromatin accessibility mapping of the striatum identifies tyrosine kinase fyn as a therapeutic target for heroin use disorder
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d88bd91ce5342d1ae6c9fd044545db3
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Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder

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