KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant metabolites. Here, we screened methanolic extracts prepared from 40 Californian coastal redwood forest plants for effects...

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Autores principales: Geoffrey W. Abbott, Kaitlyn E. Redford, Ryan F. Yoshimura, Rían W. Manville, Luiz Moreira, Kevin Tran, Grey Arena, Alexandra Kookootsedes, Emma Lasky, Elliot Gunnison
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
KCNQ channels
KCNE subunits
analgesia
botanical medicines
Native American
Physiology
QP1-981
Acceso en línea:https://doaj.org/article/1d88ec059d934e06b7925c86bbc4cd3d
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https://doaj.org/article/1d88ec059d934e06b7925c86bbc4cd3d

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