SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores

The kinetochore-bound motor CENP-E plays a critical role in chromosome alignment. Here, the authors show that NF-κB activating protein (NKAP) dynamically localises to kinetochores, is SUMOylated during mitosis, and this modification is required for NKAP to bind CENP-E and localise CENP-E to the kine...

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Autores principales:	Teng Li, Liang Chen, Juanxian Cheng, Jiang Dai, Yijiao Huang, Jian Zhang, Zhaoshan Liu, Ang Li, Na Li, Hongxia Wang, Xiaomin Yin, Kun He, Ming Yu, Tao Zhou, Xuemin Zhang, Qing Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d9387d886e04cbf92521da9a468d7b2
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spelling	oai:doaj.org-article:1d9387d886e04cbf92521da9a468d7b22021-12-02T14:39:52ZSUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores10.1038/ncomms129692041-1723https://doaj.org/article/1d9387d886e04cbf92521da9a468d7b22016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12969https://doaj.org/toc/2041-1723The kinetochore-bound motor CENP-E plays a critical role in chromosome alignment. Here, the authors show that NF-κB activating protein (NKAP) dynamically localises to kinetochores, is SUMOylated during mitosis, and this modification is required for NKAP to bind CENP-E and localise CENP-E to the kinetochore.Teng LiLiang ChenJuanxian ChengJiang DaiYijiao HuangJian ZhangZhaoshan LiuAng LiNa LiHongxia WangXiaomin YinKun HeMing YuTao ZhouXuemin ZhangQing XiaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teng Li Liang Chen Juanxian Cheng Jiang Dai Yijiao Huang Jian Zhang Zhaoshan Liu Ang Li Na Li Hongxia Wang Xiaomin Yin Kun He Ming Yu Tao Zhou Xuemin Zhang Qing Xia SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
description	The kinetochore-bound motor CENP-E plays a critical role in chromosome alignment. Here, the authors show that NF-κB activating protein (NKAP) dynamically localises to kinetochores, is SUMOylated during mitosis, and this modification is required for NKAP to bind CENP-E and localise CENP-E to the kinetochore.
format	article
author	Teng Li Liang Chen Juanxian Cheng Jiang Dai Yijiao Huang Jian Zhang Zhaoshan Liu Ang Li Na Li Hongxia Wang Xiaomin Yin Kun He Ming Yu Tao Zhou Xuemin Zhang Qing Xia
author_facet	Teng Li Liang Chen Juanxian Cheng Jiang Dai Yijiao Huang Jian Zhang Zhaoshan Liu Ang Li Na Li Hongxia Wang Xiaomin Yin Kun He Ming Yu Tao Zhou Xuemin Zhang Qing Xia
author_sort	Teng Li
title	SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
title_short	SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
title_full	SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
title_fullStr	SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
title_full_unstemmed	SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
title_sort	sumoylated nkap is essential for chromosome alignment by anchoring cenp-e to kinetochores
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1d9387d886e04cbf92521da9a468d7b2
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SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores

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