Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation

Abstract Filopodia protrude from the leading edge of cells and play important roles in cell motility. Here we report the mechanism of myosin X (encoded by Myo10)-induced multi-cycle filopodia extension. We found that actin, Arp2/3, vinculin and integrin-β first accumulated at the cell’s leading edge...

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Autores principales: Kangmin He, Tsuyoshi Sakai, Yoshikazu Tsukasaki, Tomonobu M. Watanabe, Mitsuo Ikebe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1d9aaba67a494c1db325ab4a0b2f6467
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