Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.

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Autores principales: Clémence Mooser, Ioanna-Eleni Symeonidou, Pia-Amata Leimbacher, Alison Ribeiro, Ann-Marie K. Shorrocks, Stephanie Jungmichel, Sara C. Larsen, Katja Knechtle, Arti Jasrotia, Diana Zurbriggen, Alain Jeanrenaud, Colin Leikauf, Daniel Fink, Michael L. Nielsen, Andrew N. Blackford, Manuel Stucki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614
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https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614

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