Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.
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| Lenguaje: | EN |
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614 |
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oai:doaj.org-article:1e40f7a690df46ba8c9721ca498fe6142021-12-02T14:42:29ZTreacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation10.1038/s41467-019-13981-x2041-1723https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe6142020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13981-xhttps://doaj.org/toc/2041-1723DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.Clémence MooserIoanna-Eleni SymeonidouPia-Amata LeimbacherAlison RibeiroAnn-Marie K. ShorrocksStephanie JungmichelSara C. LarsenKatja KnechtleArti JasrotiaDiana ZurbriggenAlain JeanrenaudColin LeikaufDaniel FinkMichael L. NielsenAndrew N. BlackfordManuel StuckiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Clémence Mooser Ioanna-Eleni Symeonidou Pia-Amata Leimbacher Alison Ribeiro Ann-Marie K. Shorrocks Stephanie Jungmichel Sara C. Larsen Katja Knechtle Arti Jasrotia Diana Zurbriggen Alain Jeanrenaud Colin Leikauf Daniel Fink Michael L. Nielsen Andrew N. Blackford Manuel Stucki Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| description |
DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks. |
| format |
article |
| author |
Clémence Mooser Ioanna-Eleni Symeonidou Pia-Amata Leimbacher Alison Ribeiro Ann-Marie K. Shorrocks Stephanie Jungmichel Sara C. Larsen Katja Knechtle Arti Jasrotia Diana Zurbriggen Alain Jeanrenaud Colin Leikauf Daniel Fink Michael L. Nielsen Andrew N. Blackford Manuel Stucki |
| author_facet |
Clémence Mooser Ioanna-Eleni Symeonidou Pia-Amata Leimbacher Alison Ribeiro Ann-Marie K. Shorrocks Stephanie Jungmichel Sara C. Larsen Katja Knechtle Arti Jasrotia Diana Zurbriggen Alain Jeanrenaud Colin Leikauf Daniel Fink Michael L. Nielsen Andrew N. Blackford Manuel Stucki |
| author_sort |
Clémence Mooser |
| title |
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| title_short |
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| title_full |
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| title_fullStr |
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| title_full_unstemmed |
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation |
| title_sort |
treacle controls the nucleolar response to rdna breaks via topbp1 recruitment and atr activation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614 |
| work_keys_str_mv |
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1718389676886196224 |