Interplay of <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> <italic toggle="yes">fabZ</italic> and <italic toggle="yes">lpxC</italic> Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

Interplay of <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> <italic toggle="yes">fabZ</italic> and <italic toggle="yes">lpxC</italic> Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

ABSTRACT Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery. In part...

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Detalles Bibliográficos
Autores principales: Mina Mostafavi, Lisha Wang, Lili Xie, Kenneth T. Takeoka, Daryl L. Richie, Fergal Casey, Alexey Ruzin, William S. Sawyer, Christopher M. Rath, Jun-Rong Wei, Charles R. Dean
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
LpxC
fabZ
lipid A
toxic accumulation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/1e5ff2b427e345449955f5246fb5ce69
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