Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage.
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Nature Portfolio
2021
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oai:doaj.org-article:1e6956b0bc82403cacae878852daffc32021-12-02T17:55:05ZDysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury10.1038/s41467-021-24712-62041-1723https://doaj.org/article/1e6956b0bc82403cacae878852daffc32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24712-6https://doaj.org/toc/2041-1723Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage.Wulf TonnusClaudia MeyerChristian SteinebachAlexia BelavgeniAnne von MässenhausenNadia Zamora GonzalezFrancesca MaremontiFlorian GembardtNina HimmerkusMarkus LatkSophie LockeJulian MarschnerWenjun LiSpencer ShortSebastian DollIrina IngoldBettina PronethChristoph DanielNazanin KabganiRafael KramannStephen MotikaPaul J. HergenrotherStefan R. BornsteinChristian HugoJan Ulrich BeckerKerstin AmannHans-Joachim AndersDaniel KreiselDerek PrattMichael GütschowMarcus ConradAndreas LinkermannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Wulf Tonnus Claudia Meyer Christian Steinebach Alexia Belavgeni Anne von Mässenhausen Nadia Zamora Gonzalez Francesca Maremonti Florian Gembardt Nina Himmerkus Markus Latk Sophie Locke Julian Marschner Wenjun Li Spencer Short Sebastian Doll Irina Ingold Bettina Proneth Christoph Daniel Nazanin Kabgani Rafael Kramann Stephen Motika Paul J. Hergenrother Stefan R. Bornstein Christian Hugo Jan Ulrich Becker Kerstin Amann Hans-Joachim Anders Daniel Kreisel Derek Pratt Michael Gütschow Marcus Conrad Andreas Linkermann Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| description |
Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival in a mouse model of acute kidney damage. |
| format |
article |
| author |
Wulf Tonnus Claudia Meyer Christian Steinebach Alexia Belavgeni Anne von Mässenhausen Nadia Zamora Gonzalez Francesca Maremonti Florian Gembardt Nina Himmerkus Markus Latk Sophie Locke Julian Marschner Wenjun Li Spencer Short Sebastian Doll Irina Ingold Bettina Proneth Christoph Daniel Nazanin Kabgani Rafael Kramann Stephen Motika Paul J. Hergenrother Stefan R. Bornstein Christian Hugo Jan Ulrich Becker Kerstin Amann Hans-Joachim Anders Daniel Kreisel Derek Pratt Michael Gütschow Marcus Conrad Andreas Linkermann |
| author_facet |
Wulf Tonnus Claudia Meyer Christian Steinebach Alexia Belavgeni Anne von Mässenhausen Nadia Zamora Gonzalez Francesca Maremonti Florian Gembardt Nina Himmerkus Markus Latk Sophie Locke Julian Marschner Wenjun Li Spencer Short Sebastian Doll Irina Ingold Bettina Proneth Christoph Daniel Nazanin Kabgani Rafael Kramann Stephen Motika Paul J. Hergenrother Stefan R. Bornstein Christian Hugo Jan Ulrich Becker Kerstin Amann Hans-Joachim Anders Daniel Kreisel Derek Pratt Michael Gütschow Marcus Conrad Andreas Linkermann |
| author_sort |
Wulf Tonnus |
| title |
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| title_short |
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| title_full |
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| title_fullStr |
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| title_full_unstemmed |
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| title_sort |
dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1e6956b0bc82403cacae878852daffc3 |
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