The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis

The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.

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Autores principales: Jérémie Rispal, Lucie Baron, Jean-François Beaulieu, Martine Chevillard-Briet, Didier Trouche, Fabrice Escaffit
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/1e83ac8097364333b5b7bad1e54d2002
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