The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis

The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis

The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.

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Autores principales: Jérémie Rispal, Lucie Baron, Jean-François Beaulieu, Martine Chevillard-Briet, Didier Trouche, Fabrice Escaffit
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/1e83ac8097364333b5b7bad1e54d2002
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spelling oai:doaj.org-article:1e83ac8097364333b5b7bad1e54d20022021-12-02T14:39:21ZThe H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis10.1038/s41467-019-09899-z2041-1723https://doaj.org/article/1e83ac8097364333b5b7bad1e54d20022019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09899-zhttps://doaj.org/toc/2041-1723The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.Jérémie RispalLucie BaronJean-François BeaulieuMartine Chevillard-BrietDidier TroucheFabrice EscaffitNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jérémie Rispal
Lucie Baron
Jean-François Beaulieu
Martine Chevillard-Briet
Didier Trouche
Fabrice Escaffit
The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
description The histone variant, H2A.Z is known to regulate gene expression and cell proliferation. Here the authors show that H2A.Z has a central role in the control of intestinal epithelial homeostasis in mice, by preventing terminal differentiation of intestinal progenitors.
format article
author Jérémie Rispal
Lucie Baron
Jean-François Beaulieu
Martine Chevillard-Briet
Didier Trouche
Fabrice Escaffit
author_facet Jérémie Rispal
Lucie Baron
Jean-François Beaulieu
Martine Chevillard-Briet
Didier Trouche
Fabrice Escaffit
author_sort Jérémie Rispal
title The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
title_short The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
title_full The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
title_fullStr The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
title_full_unstemmed The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
title_sort h2a.z histone variant integrates wnt signaling in intestinal epithelial homeostasis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/1e83ac8097364333b5b7bad1e54d2002
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