Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

Abstract The persistent increase of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) infections negatively impacts Tuberculosis treatment outcomes. Host-directed therapies (HDT) pose an complementing strategy, particularly since Mtb is highly successful in evading host-defense by manipulat...

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Autores principales: M. T. Heemskerk, C. J. Korbee, J. J. Esselink, C. Carvalho dos Santos, S. van Veen, I. F. Gordijn, F. Vrieling, K. V. Walburg, C. G. Engele, K. Dijkman, L. Wilson, F. A. W. Verreck, T. H. M. Ottenhoff, M. C. Haks
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/1ec152b467db4abebb49dc8f7a4e9c3c
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https://doaj.org/article/1ec152b467db4abebb49dc8f7a4e9c3c

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