Deconstructing the molecular genetics behind the PINK1/Parkin axis in Parkinson’s disease using Drosophila melanogaster as a model organism
Abstract Background Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder marked by the death of nigrostriatal dopaminergic neurons in response to the compounding effects of oxidative stress, mitochondrial dysfunction and protein aggregation. Transgenic Drosophila models have been...
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| Main Authors: | , |
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| Format: | article |
| Language: | EN |
| Published: |
SpringerOpen
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/1ed0f355987d42caa80dd5f35aa31a8c |
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