An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.

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Autores principales:	Jerod L. Ptacin, Carolina E. Caffaro, Lina Ma, Kristine M. San Jose Gall, Hans R. Aerni, Nicole V. Acuff, Rob W. Herman, Yelena Pavlova, Michael J. Pena, David B. Chen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Marcos E. Milla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
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spelling	oai:doaj.org-article:1eeb5f339edc4637a3c9f0f0c17dcf952021-12-02T15:07:49ZAn engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism10.1038/s41467-021-24987-92041-1723https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf952021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24987-9https://doaj.org/toc/2041-1723The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.Jerod L. PtacinCarolina E. CaffaroLina MaKristine M. San Jose GallHans R. AerniNicole V. AcuffRob W. HermanYelena PavlovaMichael J. PenaDavid B. ChenLilia K. KoriazovaLaura K. ShawverIngrid B. JosephMarcos E. MillaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
description	The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.
format	article
author	Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla
author_facet	Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla
author_sort	Jerod L. Ptacin
title	An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
title_short	An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
title_full	An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
title_fullStr	An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
title_full_unstemmed	An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
title_sort	engineered il-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
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An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

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