Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Wnt/β-catenin signaling regulates oligodendrocyte (OL) development. Here the authors show that Tcf7l2, a β-catenin transcriptional partner,sequentially interacts with stage-specific partners to coordinate the transitions of differentiation initiation and maturation during OL development.

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Auteurs principaux: Chuntao Zhao, Yaqi Deng, Lei Liu, Kun Yu, Liguo Zhang, Haibo Wang, Xuelian He, Jincheng Wang, Changqing Lu, Laiman N Wu, Qinjie Weng, Meng Mao, Jianrong Li, Johan H van Es, Mei Xin, Lee Parry, Steven A Goldman, Hans Clevers, Q. Richard Lu
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/1f0426bb84984cb2bac173cddf0948c3
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Internet

https://doaj.org/article/1f0426bb84984cb2bac173cddf0948c3

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