Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tract correlates with its helicity and show that the...

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Autores principales:	Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9
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spelling	oai:doaj.org-article:1f190bc76aba4d9fb248940a644fa9a92021-12-02T15:35:39ZSide chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor10.1038/s41467-019-09923-22041-1723https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a92019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09923-2https://doaj.org/toc/2041-1723Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tract correlates with its helicity and show that the polyQ helical structure is stabilized by hydrogen bonds between the Gln side chains and main chain carbonyl groups.Albert EscobedoBusra TopalMicha B. A. KunzeJuan ArandaGiulio ChiesaDaniele MungianuGaneko Bernardo-SeisdedosBahareh EftekharzadehMargarida GairíRoberta PierattelliIsabella C. FelliTammo DiercksOscar MilletJesús GarcíaModesto OrozcoRamon CrehuetKresten Lindorff-LarsenXavier SalvatellaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Albert Escobedo Busra Topal Micha B. A. Kunze Juan Aranda Giulio Chiesa Daniele Mungianu Ganeko Bernardo-Seisdedos Bahareh Eftekharzadeh Margarida Gairí Roberta Pierattelli Isabella C. Felli Tammo Diercks Oscar Millet Jesús García Modesto Orozco Ramon Crehuet Kresten Lindorff-Larsen Xavier Salvatella Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
description	Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tract correlates with its helicity and show that the polyQ helical structure is stabilized by hydrogen bonds between the Gln side chains and main chain carbonyl groups.
format	article
author	Albert Escobedo Busra Topal Micha B. A. Kunze Juan Aranda Giulio Chiesa Daniele Mungianu Ganeko Bernardo-Seisdedos Bahareh Eftekharzadeh Margarida Gairí Roberta Pierattelli Isabella C. Felli Tammo Diercks Oscar Millet Jesús García Modesto Orozco Ramon Crehuet Kresten Lindorff-Larsen Xavier Salvatella
author_facet	Albert Escobedo Busra Topal Micha B. A. Kunze Juan Aranda Giulio Chiesa Daniele Mungianu Ganeko Bernardo-Seisdedos Bahareh Eftekharzadeh Margarida Gairí Roberta Pierattelli Isabella C. Felli Tammo Diercks Oscar Millet Jesús García Modesto Orozco Ramon Crehuet Kresten Lindorff-Larsen Xavier Salvatella
author_sort	Albert Escobedo
title	Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
title_short	Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
title_full	Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
title_fullStr	Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
title_full_unstemmed	Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
title_sort	side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

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