Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.

<h4>Aims</h4>Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion of the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mice leads to nearly 100 percent protection from T1D. In this study,...

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Auteurs principaux: Shamina M Green-Mitchell, Sarah A Tersey, Banumathi K Cole, Kaiwen Ma, Norine S Kuhn, Tina Duong Cunningham, Nelly A Maybee, Swarup K Chakrabarti, Marcia McDuffie, David A Taylor-Fishwick, Raghavendra G Mirmira, Jerry L Nadler, Margaret A Morris
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/1f42c924931446b8bba73f20a5d64368
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https://doaj.org/article/1f42c924931446b8bba73f20a5d64368

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