A Short Hairpin RNA Screen of Interferon-Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response

A Short Hairpin RNA Screen of Interferon-Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response

ABSTRACT The type I interferon (IFN) signaling pathway restricts infection of many divergent families of RNA and DNA viruses by inducing hundreds of IFN-stimulated genes (ISGs), some of which have direct antiviral activity. We screened 813 short hairpin RNA (shRNA) constructs targeting 245 human ISG...

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Autores principales: Jianqing Li, Steve C. Ding, Hyelim Cho, Brian C. Chung, Michael Gale, Sumit K. Chanda, Michael S. Diamond
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2013
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/1f4c3ee4bf064ce890295a72819b2487
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