VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of...

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Autores principales:	Xing Guo, XiaoYan Sun, Di Hu, Ya-Juan Wang, Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Umesh Joshi, Yu Luo, Daria Mochly-Rosen, Xin Qi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f55ff619f9e46718fcb0202f07879be
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spelling	oai:doaj.org-article:1f55ff619f9e46718fcb0202f07879be2021-12-02T15:34:59ZVCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease10.1038/ncomms126462041-1723https://doaj.org/article/1f55ff619f9e46718fcb0202f07879be2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12646https://doaj.org/toc/2041-1723Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD.Xing GuoXiaoYan SunDi HuYa-Juan WangHisashi FujiokaRajan VyasSudha ChakrapaniAmit Umesh JoshiYu LuoDaria Mochly-RosenXin QiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
description	Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD.
format	article
author	Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi
author_facet	Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi
author_sort	Xing Guo
title	VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
title_short	VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
title_full	VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
title_fullStr	VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
title_full_unstemmed	VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
title_sort	vcp recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of huntington’s disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1f55ff619f9e46718fcb0202f07879be
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

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