Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences

Our understanding of the residue-level details of protein interactions remains incomplete. Here, the authors show sequence coevolution can be used to infer interacting proteins with residue-level details, including predicting 467 interactions de novo in the Escherichia coli cell envelope proteome.

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Autores principales: Anna G. Green, Hadeer Elhabashy, Kelly P. Brock, Rohan Maddamsetti, Oliver Kohlbacher, Debora S. Marks
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1f5d36246a5a4cf98d205592e87dd62a
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