The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

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We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases generate an epigenetic variant with structural and p...

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Autores principales: Federica Battistini, Pablo D. Dans, Montserrat Terrazas, Chiara L. Castellazzi, Guillem Portella, Mireia Labrador, Núria Villegas, Isabelle Brun-Heath, Carlos González, Modesto Orozco
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1f6de9e1bc4c478a93769f666de093a8
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