Notch1 haploinsufficiency in mice accelerates adipogenesis

Abstract Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/−) mice provided with 12-week normal or high-fat diet. Haploinsufficiency of Notch1 was associated with adipo...

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Autores principales: Kazutoshi Yamaguchi, Motoharu Hayashi, Yasuhiro Uchida, Xian Wu Cheng, Takayuki Nakayama, Tadashi Matsushita, Toyoaki Murohara, Kyosuke Takeshita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1f7ab7957a43406f90deeb9940a1187c
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