Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer

Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer

Summary: Background: Although T cell abundance in solid tumours is associated with better outcomes, it also correlates with a stroma-mediated source of immune suppression driven by TGFβ1 and poor overall survival. Whether this also is observed in non-small cell lung cancer (NSCLC) is unknown. Metho...

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Main Authors: Limei Wang, Haitang Yang, Patrick Dorn, Sabina Berezowska, Fabian Blank, Carlos Wotzkow, Thomas M. Marti, Ren-Wang Peng, Nathalie Harrer, Wolfgang Sommergruber, Gregor J. Kocher, Ralph A. Schmid, Sean R.R. Hall
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Stroma
PD-L1
T cells
Immunosuppression
TGFβ1
Lung cancer
Medicine
R
Medicine (General)
R5-920
Online Access:https://doaj.org/article/1f7d51f1822442cc8888fbc4d5daa6bb
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https://doaj.org/article/1f7d51f1822442cc8888fbc4d5daa6bb

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