A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.

Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) regulate developmental timing and longevity through the conserved nuclear hormone receptor D...

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Auteurs principaux: Joshua Wollam, Daniel B Magner, Lilia Magomedova, Elisabeth Rass, Yidong Shen, Veerle Rottiers, Bianca Habermann, Carolyn L Cummins, Adam Antebi
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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Accès en ligne:https://doaj.org/article/1fbb10ee35964a4ea240eed92e350721
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