Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorde...
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Nature Portfolio
2017
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oai:doaj.org-article:1fc27041918b48b8a2944c3034860cf12021-12-02T14:42:44ZNatural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival10.1038/ncomms160412041-1723https://doaj.org/article/1fc27041918b48b8a2944c3034860cf12017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16041https://doaj.org/toc/2041-1723The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.Konrad BuscherErik EhingerPritha GuptaAkula Bala PramodDennis WolfGeorge TweetCalvin PanCharles D. MillsAldons J. LusisKlaus LeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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Science Q Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
description |
The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans. |
format |
article |
author |
Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley |
author_facet |
Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley |
author_sort |
Konrad Buscher |
title |
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
title_short |
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
title_full |
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
title_fullStr |
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
title_full_unstemmed |
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
title_sort |
natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/1fc27041918b48b8a2944c3034860cf1 |
work_keys_str_mv |
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