Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorde...

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Autores principales:	Konrad Buscher, Erik Ehinger, Pritha Gupta, Akula Bala Pramod, Dennis Wolf, George Tweet, Calvin Pan, Charles D. Mills, Aldons J. Lusis, Klaus Ley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fc27041918b48b8a2944c3034860cf1
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spelling	oai:doaj.org-article:1fc27041918b48b8a2944c3034860cf12021-12-02T14:42:44ZNatural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival10.1038/ncomms160412041-1723https://doaj.org/article/1fc27041918b48b8a2944c3034860cf12017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16041https://doaj.org/toc/2041-1723The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.Konrad BuscherErik EhingerPritha GuptaAkula Bala PramodDennis WolfGeorge TweetCalvin PanCharles D. MillsAldons J. LusisKlaus LeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
description	The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.
format	article
author	Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley
author_facet	Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley
author_sort	Konrad Buscher
title	Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_short	Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_full	Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_fullStr	Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_full_unstemmed	Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_sort	natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1fc27041918b48b8a2944c3034860cf1
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Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

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