Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorde...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Konrad Buscher, Erik Ehinger, Pritha Gupta, Akula Bala Pramod, Dennis Wolf, George Tweet, Calvin Pan, Charles D. Mills, Aldons J. Lusis, Klaus Ley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/1fc27041918b48b8a2944c3034860cf1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:1fc27041918b48b8a2944c3034860cf1
record_format dspace
spelling oai:doaj.org-article:1fc27041918b48b8a2944c3034860cf12021-12-02T14:42:44ZNatural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival10.1038/ncomms160412041-1723https://doaj.org/article/1fc27041918b48b8a2944c3034860cf12017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16041https://doaj.org/toc/2041-1723The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.Konrad BuscherErik EhingerPritha GuptaAkula Bala PramodDennis WolfGeorge TweetCalvin PanCharles D. MillsAldons J. LusisKlaus LeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Konrad Buscher
Erik Ehinger
Pritha Gupta
Akula Bala Pramod
Dennis Wolf
George Tweet
Calvin Pan
Charles D. Mills
Aldons J. Lusis
Klaus Ley
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
description The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.
format article
author Konrad Buscher
Erik Ehinger
Pritha Gupta
Akula Bala Pramod
Dennis Wolf
George Tweet
Calvin Pan
Charles D. Mills
Aldons J. Lusis
Klaus Ley
author_facet Konrad Buscher
Erik Ehinger
Pritha Gupta
Akula Bala Pramod
Dennis Wolf
George Tweet
Calvin Pan
Charles D. Mills
Aldons J. Lusis
Klaus Ley
author_sort Konrad Buscher
title Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_short Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_full Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_fullStr Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_full_unstemmed Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
title_sort natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1fc27041918b48b8a2944c3034860cf1
work_keys_str_mv AT konradbuscher naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT erikehinger naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT prithagupta naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT akulabalapramod naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT denniswolf naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT georgetweet naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT calvinpan naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT charlesdmills naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT aldonsjlusis naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
AT klausley naturalvariationofmacrophageactivationasdiseaserelevantphenotypepredictiveofinflammationandcancersurvival
_version_ 1718389554269913088