Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells

ABSTRACT In the absence of a vaccine, multidrug-resistant Neisseria gonorrhoeae has emerged as a major human health threat, and new approaches to treat gonorrhea are urgently needed. N. gonorrhoeae pili are posttranslationally modified by a glycan that terminates in a galactose. The terminal galacto...

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Bibliographic Details
Main Authors: Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E.-C. Jen, Victor J. Torres, Jennifer L. Edwards, Michael P. Jennings
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
CR3
Online Access:https://doaj.org/article/1fed3e7d06824e47b917fbd3f86a0f24
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