Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.

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Autores principales:	Jan Rossaint, Katharina Kühne, Jennifer Skupski, Hugo Van Aken, Mark R. Looney, Andres Hidalgo, Alexander Zarbock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2006c9fe4f2c454ab4c649a9b4ba6148
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spelling	oai:doaj.org-article:2006c9fe4f2c454ab4c649a9b4ba61482021-12-02T15:34:51ZDirected transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response10.1038/ncomms134642041-1723https://doaj.org/article/2006c9fe4f2c454ab4c649a9b4ba61482016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13464https://doaj.org/toc/2041-1723Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.Jan RossaintKatharina KühneJennifer SkupskiHugo Van AkenMark R. LooneyAndres HidalgoAlexander ZarbockNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jan Rossaint Katharina Kühne Jennifer Skupski Hugo Van Aken Mark R. Looney Andres Hidalgo Alexander Zarbock Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
description	Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.
format	article
author	Jan Rossaint Katharina Kühne Jennifer Skupski Hugo Van Aken Mark R. Looney Andres Hidalgo Alexander Zarbock
author_facet	Jan Rossaint Katharina Kühne Jennifer Skupski Hugo Van Aken Mark R. Looney Andres Hidalgo Alexander Zarbock
author_sort	Jan Rossaint
title	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
title_short	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
title_full	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
title_fullStr	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
title_full_unstemmed	Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
title_sort	directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2006c9fe4f2c454ab4c649a9b4ba6148
work_keys_str_mv	AT janrossaint directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT katharinakuhne directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT jenniferskupski directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT hugovanaken directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT markrlooney directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT andreshidalgo directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse AT alexanderzarbock directedtransportofneutrophilderivedextracellularvesiclesenablesplateletmediatedinnateimmuneresponse
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Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

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