The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the proliferation of cancer cells in a mouse model.

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Autores principales: Ee Lin Wong, Eric Nawrotzky, Christoph Arkona, Boo Geun Kim, Samuel Beligny, Xinning Wang, Stefan Wagner, Michael Lisurek, Dirk Carstanjen, Jörg Rademann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a3
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