The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the proliferation of cancer cells in a mouse model.

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Autores principales:	Ee Lin Wong, Eric Nawrotzky, Christoph Arkona, Boo Geun Kim, Samuel Beligny, Xinning Wang, Stefan Wagner, Michael Lisurek, Dirk Carstanjen, Jörg Rademann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a3
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spelling	oai:doaj.org-article:2011251d4c4d4f39bd08fae3a0b285a32021-12-02T15:35:30ZThe transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation10.1038/s41467-018-07923-22041-1723https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a32019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07923-2https://doaj.org/toc/2041-1723The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the proliferation of cancer cells in a mouse model.Ee Lin WongEric NawrotzkyChristoph ArkonaBoo Geun KimSamuel BelignyXinning WangStefan WagnerMichael LisurekDirk CarstanjenJörg RademannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ee Lin Wong Eric Nawrotzky Christoph Arkona Boo Geun Kim Samuel Beligny Xinning Wang Stefan Wagner Michael Lisurek Dirk Carstanjen Jörg Rademann The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
description	The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the proliferation of cancer cells in a mouse model.
format	article
author	Ee Lin Wong Eric Nawrotzky Christoph Arkona Boo Geun Kim Samuel Beligny Xinning Wang Stefan Wagner Michael Lisurek Dirk Carstanjen Jörg Rademann
author_facet	Ee Lin Wong Eric Nawrotzky Christoph Arkona Boo Geun Kim Samuel Beligny Xinning Wang Stefan Wagner Michael Lisurek Dirk Carstanjen Jörg Rademann
author_sort	Ee Lin Wong
title	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
title_short	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
title_full	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
title_fullStr	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
title_full_unstemmed	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation
title_sort	transcription factor stat5 catalyzes mannich ligation reactions yielding inhibitors of leukemic cell proliferation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a3
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The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

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