N-acetylcholinesterase-induced apoptosis in Alzheimer's disease.

N-acetylcholinesterase-induced apoptosis in Alzheimer's disease.

<h4>Background</h4>Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phen...

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Autores principales: Debra Toiber, Amit Berson, David Greenberg, Naomi Melamed-Book, Sophia Diamant, Hermona Soreq
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/2018499a57c049bf8580dad94ba61bb7
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