Implications of TGFβ Signaling and CDK Inhibition for the Treatment of Breast Cancer
TGFβ signaling enacts tumor-suppressive functions in normal cells through promotion of several cell regulatory actions including cell-cycle control and apoptosis. Canonical TGFβ signaling proceeds through phosphorylation of the transcription factor, SMAD3, at the C-terminus of the protein. During on...
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
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MDPI AG
2021
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| Accès en ligne: | https://doaj.org/article/201ed25b35bb465cbe9f3da4b58fbc5f |
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