The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines

Abstract Background Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell phenotype associated with self-renewal and drug resistance properties. Activation of hypoxia-inducible factors (HIFs) helps in cellular adaptat...

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Autores principales: Lucy Wanjiku Macharia, Wanjiru Muriithi, Carlos Pilotto Heming, Dennis Kirii Nyaga, Veronica Aran, Marianne Wanjiru Mureithi, Valeria Pereira Ferrer, Attilio Pane, Paulo Niemeyer Filho, Vivaldo Moura-Neto
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/20243c366e754f0681fc81ee1a1413ea
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